Ontology highlight
ABSTRACT:
SUBMITTER: Winkelmann A
PROVIDER: S-EPMC4425505 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Winkelmann Aline A You Xiantian X Grünewald Nora N Häussler Ute U Krestel Heinz H Haas Carola A CA Schwarz Günter G Chen Wei W Meier Jochen C JC
PloS one 20150508 5
Establishment of phylogenetic relationships remains a challenging task because it is based on computational analysis of genomic hot spots that display species-specific sequence variations. Here, we identify a species-specific thymine-to-guanine sequence variation in the Glrb gene which gives rise to species-specific splice donor sites in the Glrb genes of mouse and bushbaby. The resulting splice insert in the receptor for the inhibitory neurotransmitter glycine (GlyR) conveys synaptic receptor c ...[more]