Ontology highlight
ABSTRACT:
SUBMITTER: Ewings KE
PROVIDER: S-EPMC1894764 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Ewings Katherine E KE Hadfield-Moorhouse Kathryn K Wiggins Ceri M CM Wickenden Julie A JA Balmanno Kathryn K Gilley Rebecca R Degenhardt Kurt K White Eileen E Cook Simon J SJ
The EMBO journal 20070524 12
The proapoptotic protein Bim is expressed de novo following withdrawal of serum survival factors. Here, we show that Bim-/- fibroblasts and epithelial cells exhibit reduced cell death following serum withdrawal in comparison with their wild-type counterparts. In viable cells, Bax associates with Bcl-2, Bcl-x(L) and Mcl-1. Upon serum withdrawal, newly expressed Bim(EL) associates with Bcl-x(L) and Mcl-1, coinciding with the dissociation of Bax from these proteins. Survival factors can prevent ass ...[more]