Ontology highlight
ABSTRACT:
SUBMITTER: Cheli Y
PROVIDER: S-EPMC1895792 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Cheli Yann Y Kunicki Thomas J TJ
Blood 20060202 11
There is a 2-fold variation in platelet integrin alpha2beta1 levels among inbred mouse strains. Decreased alpha2beta1 in 4 strains carrying Itga2 haplotype 2 results from decreased affinity of heterogeneous ribonucleoprotein L (hnRNP L) for a 6 CA repeat sequence (CA6) within intron 1. Seven strains bearing haplotype 1 and a 21 CA repeat sequence at this position (CA21) express twice the level of platelet alpha2beta1 and exhibit an equivalent gain of platelet function in vitro. By UV crosslinkin ...[more]