Ontology highlight
ABSTRACT:
SUBMITTER: Jokinen J
PROVIDER: S-EPMC2808374 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Jokinen Johanna J White Daniel J DJ Salmela Maria M Huhtala Mikko M Käpylä Jarmo J Sipilä Kalle K Puranen J Santeri JS Nissinen Liisa L Kankaanpää Pasi P Marjomäki Varpu V Hyypiä Timo T Johnson Mark S MS Heino Jyrki J
The EMBO journal 20091119 1
Conformational activation increases the affinity of integrins to their ligands. On ligand binding, further changes in integrin conformation elicit cellular signalling. Unlike any of the natural ligands of alpha2beta1 integrin, human echovirus 1 (EV1) seemed to bind more avidly a 'closed' than an activated 'open' form of the alpha2I domain. Furthermore, a mutation E336A in the alpha2 subunit, which inactivated alpha2beta1 as a collagen receptor, enhanced alpha2beta1 binding to EV1. Thus, EV1 seem ...[more]