Ontology highlight
ABSTRACT:
SUBMITTER: Finberg KE
PROVIDER: S-EPMC1899415 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Finberg Karin E KE Sequist Lecia V LV Joshi Victoria A VA Muzikansky Alona A Miller Julie M JM Han Moonjoo M Beheshti Javad J Chirieac Lucian R LR Mark Eugene J EJ Iafrate A John AJ
The Journal of molecular diagnostics : JMD 20070701 3
Somatic mutations in the epidermal growth factor receptor gene (EGFR) are detected in a subset of lung adenocarcinomas, particularly bronchioloalveolar carcinoma (BAC) and adenocarcinoma with bronchioloalveolar features (AWBF), and correlate with clinical response to tyrosine kinase inhibitors (TKIs). In contrast, lung adenocarcinomas refractory to TKIs often have activating mutations in KRAS but lack EGFR mutations. Some adenocarcinomas have mucinous histology, but the clinical and molecular si ...[more]