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3dLOGO: a web server for the identification, analysis and use of conserved protein substructures.

ABSTRACT: 3dLOGO is a web server for the identification and analysis of conserved protein 3D substructures. Given a set of residues in a PDB (Protein Data Bank) chain, the server detects the matching substructure(s) in a set of user-provided protein structures, generates a multiple structure alignment centered on the input substructures and highlights other residues whose structural conservation becomes evident after the defined superposition. Conserved residues are proposed to the user for highlighting functional areas, deriving refined structural motifs or building sequence patterns. Residue structural conservation can be visualized through an expressly designed Java application, 3dProLogo, which is a 3D implementation of a sequence logo. The 3dLOGO server, with related documentation, is available at http://3dlogo.uniroma2.it/

SUBMITTER: Via A

PROVIDER: S-EPMC1933223 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature

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3dLOGO: a web server for the identification, analysis and use of conserved protein substructures.

Via Allegra A Peluso Daniele D Gherardini Pier Federico PF de Rinaldis Emanuele E Colombo Teresa T Ausiello Gabriele G Helmer-Citterich Manuela M

Nucleic acids research 20070508 Web Server issue

3dLOGO is a web server for the identification and analysis of conserved protein 3D substructures. Given a set of residues in a PDB (Protein Data Bank) chain, the server detects the matching substructure(s) in a set of user-provided protein structures, generates a multiple structure alignment centered on the input substructures and highlights other residues whose structural conservation becomes evident after the defined superposition. Conserved residues are proposed to the user for highlighting f ...[more]

PMID: 17488847

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