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Use of multiplex PCR to identify Staphylococcus aureus adhesins involved in human hematogenous infections.

ABSTRACT: We have developed a multiplex PCR procedure to determine the distribution of nine adhesin genes in Staphylococcus aureus isolates. Only genes encoding bone sialoprotein binding protein and fibronectin binding protein B were significantly associated with hematogenous osteomyelitis/arthritis and native-valve endocarditis, respectively, suggesting their involvement in hematogenous tissue infections.

SUBMITTER: Tristan A

PROVIDER: S-EPMC193818 | biostudies-literature | 2003 Sep

REPOSITORIES: biostudies-literature

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Use of multiplex PCR to identify Staphylococcus aureus adhesins involved in human hematogenous infections.

Tristan Anne A Ying Liu L Bes Michele M Etienne Jerome J Vandenesch Francois F Lina Gerard G

Journal of clinical microbiology 20030901 9

We have developed a multiplex PCR procedure to determine the distribution of nine adhesin genes in Staphylococcus aureus isolates. Only genes encoding bone sialoprotein binding protein and fibronectin binding protein B were significantly associated with hematogenous osteomyelitis/arthritis and native-valve endocarditis, respectively, suggesting their involvement in hematogenous tissue infections. ...[more]

PMID: 12958296

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