Ontology highlight
ABSTRACT:
SUBMITTER: Valdez G
PROVIDER: S-EPMC1941461 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Valdez Gregorio G Philippidou Polyxeni P Rosenbaum Julie J Akmentin Wendy W Shao Yufang Y Halegoua Simon S
Proceedings of the National Academy of Sciences of the United States of America 20070717 30
Why neurotrophins and their Trk receptors promote neuronal differentiation and survival whereas receptor tyrosine kinases for other growth factors, such as EGF, do not, has been a long-standing question in neurobiology. We provide evidence that one difference lies in the selective ability of Trk to generate long-lived signaling endosomes. We show that Trk endocytosis is distinguished from the classical clathrin-based endocytosis of EGF receptor (EGFR). Although Trk and EGFR each stimulate membra ...[more]