Ontology highlight
ABSTRACT:
SUBMITTER: Guo D
PROVIDER: S-EPMC1965458 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Guo Dagang D Tan Ying-cai YC Wang Dawei D Madhusoodanan K S KS Zheng Yi Y Maack Thomas T Zhang J Jillian JJ Huang Xin-Yun XY
Cell 20070101 2
The small GTPase Rac and the second messenger cGMP (guanosine 3',5'-cyclic monophosphate) are critical regulators of diverse cell functions. When activated by extracellular signals via membrane signaling receptors, Rac executes its functions through engaging downstream effectors such as p21-activated kinase (PAK), a serine/threonine protein kinase. However, the molecular mechanism by which membrane signaling receptors regulate cGMP levels is not known. Here we have uncovered a signaling pathway ...[more]