Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells.
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ABSTRACT:
SUBMITTER: Chung KM
PROVIDER: S-EPMC1951387 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Publications
Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells.
Chung Kyung Min KM Thompson Bruce S BS Fremont Daved H DH Diamond Michael S MS
Journal of virology 20070620 17
Previous studies have suggested that monoclonal antibodies (MAbs) to flavivirus nonstructural protein-1 (NS-1) protect against infection in mice through an Fc-gamma receptor-dependent pathway. To identify a specific mechanism, we evaluated the protective activity of anti-NS1 MAbs to WNV using mice and cells with deficiencies of specific Fc-gamma receptors. Our results suggest that only MAbs that recognize cell surface-associated NS1 trigger Fc-gamma receptor I- and/or IV-mediated phagocytosis an ...[more]
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