Ontology highlight
ABSTRACT:
SUBMITTER: Pagant S
PROVIDER: S-EPMC1951769 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Pagant Silvere S Kung Leslie L Dorrington Mariana M Lee Marcus C S MC Miller Elizabeth A EA
Molecular biology of the cell 20070705 9
Capture of newly synthesized proteins into endoplasmic reticulum (ER)-derived coat protomer type II (COPII) vesicles represents a critical juncture in the quality control of protein biogenesis within the secretory pathway. The yeast ATP-binding cassette transporter Yor1p is a pleiotropic drug pump that shows homology to the human cystic fibrosis transmembrane conductance regulator (CFTR). Deletion of a phenylalanine residue in Yor1p, equivalent to the major disease-causing mutation in CFTR, caus ...[more]