Ontology highlight
ABSTRACT:
SUBMITTER: Bhattacharyya D
PROVIDER: S-EPMC1805085 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Bhattacharyya Dibyendu D Glick Benjamin S BS
Molecular biology of the cell 20061227 3
Budding yeast Sec16 is a large peripheral endoplasmic reticulum (ER) membrane protein that functions in generating COPII transport vesicles and in clustering COPII components at transitional ER (tER) sites. Sec16 interacts with multiple COPII components. Although the COPII assembly pathway is evolutionarily conserved, Sec16 homologues have not been described in higher eukaryotes. Here, we show that mammalian cells contain two distinct Sec16 homologues: a large protein that we term Sec16L and a s ...[more]