Ontology highlight
ABSTRACT:
SUBMITTER: Thuault S
PROVIDER: S-EPMC5007086 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Thuault Sylvie S Comunale Franck F Hasna Jessy J Fortier Mathieu M Planchon Damien D Elarouci Nabila N De Reynies Aurélien A Bodin Stéphane S Blangy Anne A Gauthier-Rouvière Cécile C
Molecular biology of the cell 20160713 17
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of skeletal muscle origin in children and adolescents. Among RMS subtypes, alveolar rhabdomyosarcoma (ARMS), which is characterized by the presence of the PAX3-FOXO1A or PAX7-FOXO1A chimeric oncogenic transcription factor, is associated with poor prognosis and a strong risk of metastasis compared with the embryonal subtype (ERMS). To identify molecular pathways involved in ARMS aggressiveness, we first characterized the migratory beha ...[more]