Ontology highlight
ABSTRACT:
SUBMITTER: Buck J
PROVIDER: S-EPMC2000436 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Buck Janina J Fürtig Boris B Noeske Jonas J Wöhnert Jens J Schwalbe Harald H
Proceedings of the National Academy of Sciences of the United States of America 20070925 40
Structural transitions of RNA between alternate conformations with similar stabilities are associated with important aspects of cellular function. Few techniques presently exist that are capable of monitoring such transitions and thereby provide insight into RNA dynamics and function at atomic resolution. Riboswitches are found in the 5'-UTR of mRNA and control gene expression through structural transitions after ligand recognition. A time-resolved NMR strategy was established in conjunction wit ...[more]