Ontology highlight
ABSTRACT:
SUBMITTER: Dadiboyena S
PROVIDER: S-EPMC2031838 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Tetrahedron letters 20070201 7
The regioselective synthesis of 3,5-disubstituted isoxazoles was achieved through the 1,3-dipolar cycloaddition of nitrile oxides with 1,1-disubstituted bromoalkenes. The substituted bromoalkenes function as alkyne synthons which were used to construct 5,5-disubstituted bromoisoxazoline intermediates that aromatize to the analogous isoxazoles through the loss of HBr. ...[more]