Ontology highlight
ABSTRACT:
SUBMITTER: Li B
PROVIDER: S-EPMC2031848 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Li Bo B Woo Ran-Sook RS Mei Lin L Malinow Roberto R
Neuron 20070501 4
Neuregulin-1 (NRG1) signaling participates in numerous neurodevelopmental processes. Through linkage analysis, nrg1 has been associated with schizophrenia, although its pathophysiological role is not understood. The prevailing models of schizophrenia invoke hypofunction of the glutamatergic synapse and defects in early development of hippocampal-cortical circuitry. Here, we show that the erbB4 receptor, as a postsynaptic target of NRG1, plays a key role in activity-dependent maturation and plast ...[more]