Ontology highlight
ABSTRACT:
SUBMITTER: Sun Y
PROVIDER: S-EPMC5310354 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Sun Yanjun Y Ikrar Taruna T Davis Melissa F MF Gong Nian N Zheng Xiaoting X Luo Z David ZD Lai Cary C Mei Lin L Holmes Todd C TC Gandhi Sunil P SP Xu Xiangmin X
Neuron 20160915 1
Experience alters cortical networks through neural plasticity mechanisms. During a developmental critical period, the most dramatic consequence of occluding vision through one eye (monocular deprivation) is a rapid loss of excitatory synaptic inputs to parvalbumin-expressing (PV) inhibitory neurons in visual cortex. Subsequent cortical disinhibition by reduced PV cell activity allows for excitatory ocular dominance plasticity. However, the molecular mechanisms underlying critical period synaptic ...[more]