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Neuregulin-ErbB4 signaling in the developing lung alveolus: a brief review.

ABSTRACT: Lung immaturity is the major cause of morbidity and mortality in premature infants, especially those born <28 weeks gestation. Proper lung development from 23-28 weeks requires coordinated cell proliferation and differentiation. Infants born at this age are at high risk for respiratory distress syndrome (RDS), a lung disease characterized by insufficient surfactant production due to immaturity of the alveoli and its constituent cells in the lung. The ErbB4 receptor and its stimulation by neuregulin (NRG) plays a critical role in surfactant synthesis by alveolar type II epithelial cells. In this review, we first provide an introduction to normal human alveolar development, followed by a discussion of the neuregulin and ErbB4-mediated mechanisms regulating alveolar development and surfactant production.

SUBMITTER: Fiaturi N

PROVIDER: S-EPMC4063996 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Neuregulin-ErbB4 signaling in the developing lung alveolus: a brief review.

Fiaturi Najla N Castellot John J JJ Nielsen Heber C HC

Journal of cell communication and signaling 20140531 2

Lung immaturity is the major cause of morbidity and mortality in premature infants, especially those born <28 weeks gestation. Proper lung development from 23-28 weeks requires coordinated cell proliferation and differentiation. Infants born at this age are at high risk for respiratory distress syndrome (RDS), a lung disease characterized by insufficient surfactant production due to immaturity of the alveoli and its constituent cells in the lung. The ErbB4 receptor and its stimulation by neuregu ...[more]

PMID: 24878836

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