Ontology highlight
ABSTRACT:
SUBMITTER: Yoo JC
PROVIDER: S-EPMC2034505 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Yoo Jae Cheal JC Hayman Michael J MJ
Biochemical and biophysical research communications 20070319 4
The protein tyrosine phosphatase SHP2 is a positive effector of EGFR signaling. To improve our understanding of SHP2's function, we searched for additional binding proteins of SHP2. We found that Annexin II is an SHP2-binding protein. Physical interactions of SHP2 with Annexin II were confirmed in vivo. Furthermore, binding of SHP2 with Annexin II was regulated somewhat by EGF treatment and the extracellular Ca2+ chelator, EGTA. Previously, we reported that HSP70 levels can influence the binding ...[more]