Ontology highlight
ABSTRACT:
SUBMITTER: Jang J
PROVIDER: S-EPMC5587741 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Jang Jihye J Kim Mi Ra MR Kim Taek-Keun TK Lee Woo Ran WR Kim Jong Heon JH Heo Kyun K Lee Sukmook S
Scientific reports 20170906 1
CLEC14a (C-type lectin domain family 14 member) is a tumor endothelial cell marker protein that is known to play an important role in tumor angiogenesis, but the basic molecular mechanisms underlying this function have not yet been clearly elucidated. In this study, using various proteomic tools, we isolated a 70-kDa protein that interacts with the C-type lectin-like domain of CLEC14a (CLEC14a-CTLD) and identified it as heat shock protein 70-1A (HSP70-1A). Co-immunoprecipitation showed that HSP7 ...[more]