Unknown

Dataset Information

0

Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice.


ABSTRACT: Histamine receptor H1 (H1R) is a susceptibility gene in both experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune orchitis (EAO), 2 classical T cell-mediated models of organ-specific autoimmune disease. Here we showed that expression of H1R in naive CD4+ T cells was required for maximal IFN-gamma production but was dispensable for proliferation. Moreover, H1R signaling at the time of TCR ligation was required for activation of p38 MAPK, a known regulator of IFN-gamma expression. Importantly, selective reexpression of H1R in CD4+ T cells fully complemented both the IFN-gamma production and the EAE susceptibility of H1R-deficient mice. These data suggest that the presence of H1R in CD4+ T cells and its interaction with histamine regulates early TCR signals that lead to Th1 differentiation and autoimmune disease.

SUBMITTER: Noubade R 

PROVIDER: S-EPMC2040322 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3833674 | biostudies-literature
| S-EPMC4412777 | biostudies-literature
| S-EPMC4297685 | biostudies-literature
| S-EPMC4643444 | biostudies-literature
| S-EPMC6288935 | biostudies-literature
| S-EPMC8121546 | biostudies-literature
| S-EPMC3697841 | biostudies-literature
| S-EPMC3179907 | biostudies-literature
| S-EPMC1448167 | biostudies-literature
| S-EPMC8451891 | biostudies-literature