Ontology highlight
ABSTRACT:
SUBMITTER: Zhu X
PROVIDER: S-EPMC4722862 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Zhu Xueyong X Viswanathan Karthik K Raman Rahul R Yu Wenli W Sasisekharan Ram R Wilson Ian A IA
Cell reports 20151112 8
Avian H5N1 influenza viruses continue to spread in wild birds and domestic poultry with sporadic infection in humans. Receptor binding specificity changes are a prerequisite for H5N1 viruses and other zoonotic viruses to be transmitted among humans. Previous reported hemagglutinin (HA) mutants from ferret-transmissible H5N1 viruses of A/Vietnam/1203/2004 and A/Indonesia/5/2005 showed slightly increased, but still very weak, binding to human receptors. From mutagenesis and glycan array studies, w ...[more]