Ontology highlight
ABSTRACT:
SUBMITTER: Duvall JR
PROVIDER: S-EPMC4937797 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Antiviral research 20160406
Respiratory syncytial virus (RSV) infections affect millions of children and adults every year. Despite the significant disease burden, there are currently no safe and effective vaccines or therapeutics. We employed a replicon-based high throughput screen combined with live-virus triaging assays to identify three novel diversity-oriented synthesis-derived scaffolds with activity against RSV. One of these small molecules is shown to target the RSV polymerase (L protein) to inhibit viral replicati ...[more]