Ontology highlight
ABSTRACT:
SUBMITTER: Hu S
PROVIDER: S-EPMC6673701 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Hu Shichen S Guo Yujiao Y Wang Yingli Y Li Ying Y Fu Tao T Zhou Zixuan Z Wang Yaru Y Liu Jianping J Pan Lifeng L
Nature communications 20190801 1
Myosin VI plays crucial roles in diverse cellular processes. In autophagy, Myosin VI can facilitate the maturation of autophagosomes through interactions with Tom1 and the autophagy receptors, Optineurin, NDP52 and TAX1BP1. Here, we report the high-resolution crystal structure of the C-terminal cargo-binding domain (CBD) of Myosin VI in complex with Tom1, which elucidates the mechanistic basis underpinning the specific interaction between Myosin VI and Tom1, and uncovers that the C-terminal CBD ...[more]