Ontology highlight
ABSTRACT:
SUBMITTER: Ma Y
PROVIDER: S-EPMC2064562 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Ma Yinghua Y Li Jianxue J Chiu Isaac I Wang Yawen Y Sloane Jacob A JA Lü Jining J Kosaras Bela B Sidman Richard L RL Volpe Joseph J JJ Vartanian Timothy T
The Journal of cell biology 20061001 2
Toll receptors in Drosophila melanogaster function in morphogenesis and host defense. Mammalian orthologues of Toll, the Toll-like receptors (TLRs), have been studied extensively for their essential functions in controlling innate and adaptive immune responses. We report that TLR8 is dynamically expressed during mouse brain development and localizes to neurons and axons. Agonist stimulation of TLR8 in cultured cortical neurons causes inhibition of neurite outgrowth and induces apoptosis in a dis ...[more]