Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi N
PROVIDER: S-EPMC5586349 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Takahashi Nozomu N Onozuka Wataru W Watanabe Seiji S Wakasugi Keisuke K
FEBS open bio 20170814 9
Neuroglobin (Ngb) is a heme protein expressed in the vertebrate brain. We previously engineered a chimeric Ngb protein, in which module M1 of human Ngb is replaced by that of zebrafish Ngb, and showed that the chimeric ZHHH Ngb has a cell membrane-penetrating activity similar to that of zebrafish Ngb and also rescues cells from death caused by hypoxia/reoxygenation as does human Ngb. Recently, it was reported that overexpression of mammalian Ngb in neuronal cells induces neurite outgrowth. In th ...[more]