Ontology highlight
ABSTRACT:
SUBMITTER: Yam PT
PROVIDER: S-EPMC2064654 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Yam Patricia T PT Wilson Cyrus A CA Ji Lin L Hebert Benedict B Barnhart Erin L EL Dye Natalie A NA Wiseman Paul W PW Danuser Gaudenz G Theriot Julie A JA
The Journal of cell biology 20070901 7
We have analyzed the spontaneous symmetry breaking and initiation of actin-based motility in keratocytes (fish epithelial cells). In stationary keratocytes, the actin network flow was inwards and radially symmetric. Immediately before motility initiation, the actin network flow increased at the prospective cell rear and reoriented in the perinuclear region, aligning with the prospective axis of movement. Changes in actin network flow at the cell front were detectable only after cell polarization ...[more]