Ontology highlight
ABSTRACT:
SUBMITTER: Wu LY
PROVIDER: S-EPMC2065856 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20070821 23
To identify the pharmacophore of a phosphoramidate peptidomimetic inhibitor of prostate-specific membrane antigen (PSMA), a small analog library was designed and screened for inhibitory potency against PSMA. The design of the lead inhibitor was based upon N-acyl derivatives of endogenous substrate folyl-gamma-Glu and incorporates a phosphoramidate group to interact with the PSMA catalytic zinc atoms. The scope of the analog library was designed to test the importance of various functional groups ...[more]