Ontology highlight
ABSTRACT:
SUBMITTER: Ley CR
PROVIDER: S-EPMC7588815 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20150429 12
Prostate-specific membrane antigen (PSMA) is a cell-surface enzyme-biomarker that is actively pursued for targeted delivery of imaging and therapeutic agents for prostate cancer. Our lab has developed PSMA inhibitors based on a phosphoramidate scaffold, which has shown both high selectivity for PSMA-positive tumors and rapid clearance in vivo when radiolabeled with (18)F. However, this scaffold exhibits hydrolytic instability under low pH and high temperature conditions, barring the use of other ...[more]