Ontology highlight
ABSTRACT:
SUBMITTER: Park J
PROVIDER: S-EPMC2088803 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Park Junguk J Jagasia Reshma R Kaufmann Gunnar F GF Mathison John C JC Ruiz Diana I DI Moss Jason A JA Meijler Michael M MM Ulevitch Richard J RJ Janda Kim D KD
Chemistry & biology 20071001 10
Quorum sensing (QS) is the process through which bacteria communicate utilizing small diffusible molecules termed autoinducers. It has been demonstrated that QS controls a plethora of microbial processes including the expression of virulence factors. Here we report an immunopharmacotherapeutic approach for the attenuation of QS in the Gram-positive human pathogen Staphylococcus aureus. An anti-autoinducer monoclonal antibody, AP4-24H11, was elicited against a rationally designed hapten, and effi ...[more]