Ontology highlight
ABSTRACT:
SUBMITTER: Destaing O
PROVIDER: S-EPMC3857171 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Destaing Olivier O Ferguson Shawn M SM Grichine Alexei A Oddou Christiane C De Camilli Pietro P Albiges-Rizo Corinne C Baron Roland R
PloS one 20131209 12
The large GTPase dynamin plays a key role in endocytosis but is also localized at numerous actin rich sites. We investigated dynamin functions at podosomes/invadosomes, actin-based cellular adhesion structures implicated in tissue invasion. Podosomes/invadosomes are constituted of long F-actin bundles perpendicular to the substratum (actin cores), connected to randomly arranged F-actin fibers parallel to the substratum (actin cloud). We show here that dynamin depletion in v-Src-transformed fibro ...[more]