Ontology highlight
ABSTRACT:
SUBMITTER: Sansone P
PROVIDER: S-EPMC2096439 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Sansone Pasquale P Storci Gianluca G Tavolari Simona S Guarnieri Tiziana T Giovannini Catia C Taffurelli Mario M Ceccarelli Claudio C Santini Donatella D Paterini Paola P Marcu Kenneth B KB Chieco Pasquale P Bonafè Massimiliano M
The Journal of clinical investigation 20071201 12
High serum levels of IL-6 correlate with poor outcome in breast cancer patients. However, no data are available on the relationship between IL-6 and mammary stem/progenitor cells, which may fuel the genesis of breast cancer in vivo. Herein, we address this issue in the MCF-7 breast cancer cell line and in primary human mammospheres (MS), multicellular structures enriched in stem/progenitor cells of the mammary gland. MS from node invasive breast carcinoma tissues expressed IL-6 mRNA at higher le ...[more]