Ontology highlight
ABSTRACT:
SUBMITTER: Torres M
PROVIDER: S-EPMC2110899 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Torres Marcela M Fernandez-Fuentes Narcis N Fiser András A Casadevall Arturo A
PloS one 20071212 12
Mouse-human chimeric antibodies composed of murine variable (V) and human (C) chains are useful therapeutic reagents. Consequently, we investigated whether heterologous C-regions from mice and humans affected specificity and affinity, and determined the contribution of C(H) glycosylation to antigen binding. The interaction of a 12-mer peptide mimetic with monoclonal antibody (mAb) 18B7 to Cryptococcus neoformans glucuronoxylomannan, and its chimeric (ch) and deglycosylated forms were studied by ...[more]