Ontology highlight
ABSTRACT:
SUBMITTER: Cuadrado M
PROVIDER: S-EPMC2118201 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Cuadrado Myriam M Martinez-Pastor Barbara B Murga Matilde M Toledo Luis I LI Gutierrez-Martinez Paula P Lopez Eva E Fernandez-Capetillo Oscar O
The Journal of experimental medicine 20060206 2
DNA double-strand breaks (DSBs) are among the most deleterious lesions that can challenge genomic integrity. Concomitant to the repair of the breaks, a rapid signaling cascade must be coordinated at the lesion site that leads to the activation of cell cycle checkpoints and/or apoptosis. In this context, ataxia telangiectasia mutated (ATM) and ATM and Rad-3-related (ATR) protein kinases are the earliest signaling molecules that are known to initiate the transduction cascade at damage sites. The c ...[more]