Ontology highlight
ABSTRACT:
SUBMITTER: Mouche A
PROVIDER: S-EPMC6889383 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Mouche Audrey A Archambeau Jérôme J Ricordel Charles C Chaillot Laura L Bigot Nicolas N Guillaudeux Thierry T Grenon Muriel M Pedeux Rémy R
Cell death and differentiation 20190225 11
Inhibitor of Growth 3 (ING3) is a candidate tumor suppressor gene whose expression is lost in tumors such as hepatocellular carcinoma, head and neck squamous cell carcinoma and melanoma. In the present study, we show that ING3-depleted human cells and yeast cells deleted for its ortholog YNG2 are sensitive to DNA damage suggesting a conserved role in response to such stress. In human cells, ING3 is recruited to DNA double strand breaks and is required for ATM activation. Remarkably, in response ...[more]