Ontology highlight
ABSTRACT:
SUBMITTER: Shanbhag NM
PROVIDER: S-EPMC2920610 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Shanbhag Niraj M NM Rafalska-Metcalf Ilona U IU Balane-Bolivar Carlo C Janicki Susan M SM Greenberg Roger A RA
Cell 20100601 6
DNA double-strand breaks (DSBs) initiate extensive local and global alterations in chromatin structure, many of which depend on the ATM kinase. Histone H2A ubiquitylation (uH2A) on chromatin surrounding DSBs is one example, thought to be important for recruitment of repair proteins. uH2A is also implicated in transcriptional repression; an intriguing yet untested hypothesis is that this function is conserved in the context of DSBs. Using a novel reporter that allows for visualization of repair p ...[more]