Ontology highlight
ABSTRACT:
SUBMITTER: Goldszmid RS
PROVIDER: S-EPMC2118487 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Goldszmid Romina S RS Bafica Andre A Jankovic Dragana D Feng Carl G CG Caspar Pat P Winkler-Pickett Robin R Trinchieri Giorgio G Sher Alan A
The Journal of experimental medicine 20071008 11
To investigate if transporter associated with antigen processing (TAP)-1 is required for CD8(+) T cell-mediated control of Toxoplasma gondii in vivo, we compared the resistance of TAP-1(-/-), CD8(-/-), and wild-type (WT) mice to infection with the parasite. Unexpectedly, TAP-1(-/-) mice displayed greater susceptibility than CD8(-/-), beta(2)-microglobulin(-/-) (beta(2)m(-/-)), or WT mice to infection with an avirulent parasite strain. The decreased resistance of the TAP-1(-/-) mice correlated wi ...[more]