Ontology highlight
ABSTRACT:
SUBMITTER: Skokos D
PROVIDER: S-EPMC2118646 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Skokos Dimitris D Nussenzweig Michel C MC
The Journal of experimental medicine 20070618 7
Toll-like receptor (TLR) ligation is believed to skew T cell responses toward T helper (Th)1 differentiation by inducing interleukin (IL)-12 secretion by CD8(+) dendritic cells (DCs). However, TLR-dependent Th1 responses occur in the absence of IL-12. To determine how DCs induce Th1 differentiation in the absence of IL-12, we examined the response of IL-12-deficient DCs to bacterial lipopolysaccharide (LPS). We find that LPS activates MyD88-dependent Delta 4 Notch-like ligand expression by CD8(- ...[more]