Ontology highlight
ABSTRACT:
SUBMITTER: Shirihai OS
PROVIDER: S-EPMC212759 | biostudies-literature | 2000 Jun
REPOSITORIES: biostudies-literature
Shirihai O S OS Gregory T T Yu C C Orkin S H SH Weiss M J MJ
The EMBO journal 20000601 11
Transcription factor GATA-1 is essential for normal erythropoiesis. GATA-binding sites are consistently found in promoters or enhancers of genes expressed selectively in erythroid cells. To discover novel GATA-1-regulated genes, we searched for GATA-1-activated transcripts in G1E cells, an erythroid line derived from GATA-1(-) embryonic stem cells. By subtractive analysis, we identified a new ATP-binding cassette (ABC) transporter that is strongly and rapidly induced by GATA-1. This protein, nam ...[more]