Ontology highlight
ABSTRACT:
SUBMITTER: Molina I
PROVIDER: S-EPMC2132616 | biostudies-literature | 1997 Dec
REPOSITORIES: biostudies-literature
Molina I I Baars S S Brill J A JA Hales K G KG Fuller M T MT Ripoll P P
The Journal of cell biology 19971201 6
The tiovivo (tio) gene of Drosophila encodes a kinesin-related protein, KLP38B, that colocalizes with condensed chromatin during cell division. Wild-type function of the tio gene product KLP38B is required for normal chromosome segregation during mitosis. Mitotic cells in tio larval brains displayed circular mitotic figures, increased ploidy, and abnormal anaphase figures. KLP38B mRNA is maternally provided and expressed in cells about to undergo division. We propose that KLP38B, perhaps redunda ...[more]