Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma.
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ABSTRACT:
SUBMITTER: Schoenborn JR
PROVIDER: S-EPMC2144744 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Publications
Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma.
Schoenborn Jamie R JR Dorschner Michael O MO Sekimata Masayuki M Santer Deanna M DM Shnyreva Maria M Fitzpatrick David R DR Stamatoyannopoulos John A JA Wilson Christopher B CB
Nature immunology 20070603 7
Unlike the well defined T helper type 2 cytokine locus, little is known about the regulatory elements that govern the expression of Ifng, which encodes the 'signature' T helper type 1 cytokine interferon-gamma. Here our evolutionary analysis showed that the mouse Ifng locus diverged from the ancestral locus as a result of structural rearrangements producing deletion of the neighboring gene encoding interleukin 26 and disrupting synteny 57 kilobases upstream of Ifng. Proximal to that disruption, ...[more]
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