Ontology highlight
ABSTRACT:
SUBMITTER: Clamp M
PROVIDER: S-EPMC2148306 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Clamp Michele M Fry Ben B Kamal Mike M Xie Xiaohui X Cuff James J Lin Michael F MF Kellis Manolis M Lindblad-Toh Kerstin K Lander Eric S ES
Proceedings of the National Academy of Sciences of the United States of America 20071126 49
Although the Human Genome Project was completed 4 years ago, the catalog of human protein-coding genes remains a matter of controversy. Current catalogs list a total of approximately 24,500 putative protein-coding genes. It is broadly suspected that a large fraction of these entries are functionally meaningless ORFs present by chance in RNA transcripts, because they show no evidence of evolutionary conservation with mouse or dog. However, there is currently no scientific justification for exclud ...[more]