Ontology highlight
ABSTRACT:
SUBMITTER: Kaizuka Y
PROVIDER: S-EPMC2154425 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Kaizuka Yoshihisa Y Douglass Adam D AD Varma Rajat R Dustin Michael L ML Vale Ronald D RD
Proceedings of the National Academy of Sciences of the United States of America 20071212 51
T cells interacting with antigen-presenting cells (APCs) form an "immunological synapse" (IS), a bull's-eye pattern composed of a central supramolecular activation cluster enriched with T cell receptors (TCRs) surrounded by a ring of adhesion molecules (a peripheral supramolecular activation cluster). The mechanism responsible for segregating TCR and adhesion molecules remains poorly understood. Here, we show that immortalized Jurkat T cells interacting with a planar lipid bilayer (mimicking an ...[more]