Ontology highlight
ABSTRACT:
SUBMITTER: Schroeder SJ
PROVIDER: S-EPMC2167971 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Schroeder Susan J SJ Blaha Gregor G Moore Peter B PB
Antimicrobial agents and chemotherapy 20070730 12
Negamycin, a small-molecule inhibitor of protein synthesis, binds the Haloarcula marismortui 50S ribosomal subunit at a single site formed by highly conserved RNA nucleotides near the cytosolic end of the nascent chain exit tunnel. The mechanism of antibiotic action and the function of this unexplored tunnel region remain intriguingly elusive. ...[more]