Ontology highlight
ABSTRACT:
SUBMITTER: Hendriksen J
PROVIDER: S-EPMC2171279 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Hendriksen Jolita J Fagotto Francois F van der Velde Hella H van Schie Martijn M Noordermeer Jasprien J Fornerod Maarten M
The Journal of cell biology 20051128 5
beta-Catenin is the nuclear effector of the Wnt signaling cascade. The mechanism by which nuclear activity of beta-catenin is regulated is not well defined. Therefore, we used the nuclear marker RanGTP to screen for novel nuclear beta-catenin binding proteins. We identified a cofactor of chromosome region maintenance 1 (CRM1)-mediated nuclear export, Ran binding protein 3 (RanBP3), as a novel beta-catenin-interacting protein that binds directly to beta-catenin in a RanGTP-stimulated manner. RanB ...[more]