Ontology highlight
ABSTRACT:
SUBMITTER: Dai F
PROVIDER: S-EPMC2676691 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Dai Fangyan F Lin Xia X Chang Chenbei C Feng Xin-Hua XH
Developmental cell 20090301 3
Smad2 and Smad3 (Smad2/3) are key intracellular signal transducers for TGF-beta signaling, and their transcriptional activities are controlled through reversible phosphorylation and nucleocytoplasmic shuttling. However, the precise mechanism underlying nuclear export of Smad2/3 remains elusive. Here we report the essential function of RanBP3 in selective nuclear export of Smad2/3 in the TGF-beta pathway. RanBP3 directly recognizes dephosphorylated Smad2/3, which results from the activity of nucl ...[more]