Ontology highlight
ABSTRACT:
SUBMITTER: Dai F
PROVIDER: S-EPMC3207100 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Dai Fangyan F Shen Tao T Li Zhaoyong Z Lin Xia X Feng Xin-Hua XH
EMBO reports 20111028 11
Smad2 and Smad3 (Smad2/3) are essential signal transducers and transcription factors in the canonical transforming growth factor-β (TGF-β) signalling pathway. Active Smad2/3 signalling in the nucleus is terminated by dephosphorylation and subsequent nuclear export of Smad2/3. Here we report that protein phosphatase PPM1A regulates the nuclear export of Smad2/3 through targeting nuclear exporter RanBP3. PPM1A directly interacted with and dephosphorylated RanBP3 at Ser 58 in vitro and in vivo. Con ...[more]