Ontology highlight
ABSTRACT:
SUBMITTER: Dujardin DL
PROVIDER: S-EPMC2173723 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Dujardin Denis L DL Barnhart Lora E LE Stehman Stephanie A SA Gomes Edgar R ER Gundersen Gregg G GG Vallee Richard B RB
The Journal of cell biology 20031201 6
Cytoplasmic dynein has been implicated in numerous aspects of intracellular movement. We recently found dynein inhibitors to interfere with the reorientation of the microtubule cytoskeleton during healing of wounded NIH3T3 cell monolayers. We now find that dynein and its regulators dynactin and LIS1 localize to the leading cell cortex during this process. In the presence of serum, bright diffuse staining was observed in regions of active ruffling. This pattern was abolished by cytochalasin D, an ...[more]