Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice.

ABSTRACT:

Rationale

Mechanical ventilation (MV) is an indispensable therapy for critically ill patients with acute lung injury and the adult respiratory distress syndrome. However, the mechanisms by which conventional MV induces lung injury remain unclear.

Objectives

We hypothesized that disruption of the gene encoding Nrf2, a transcription factor that regulates the induction of several antioxidant enzymes, enhances susceptibility to ventilator-induced lung injury (VILI) and that antioxidant supplementation attenuates this effect.

Methods

To test our hypothesis and to examine the relevance of oxidative stress in VILI, we assessed lung injury and inflammatory responses in Nrf2-deficient (Nrf2(-/-)) mice and wild-type (Nrf2(+/+)) mice after an acute (2-h) injurious model of MV wi

SUBMITTER: Papaiahgari S 

PROVIDER: S-EPMC2176106 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature