Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi K
PROVIDER: S-EPMC2185068 | biostudies-literature | 1999 May
REPOSITORIES: biostudies-literature
Takahashi K K Nakanishi H H Miyahara M M Mandai K K Satoh K K Satoh A A Nishioka H H Aoki J J Nomoto A A Mizoguchi A A Takai Y Y
The Journal of cell biology 19990501 3
We have isolated a novel actin filament-binding protein, named afadin, localized at cadherin-based cell-cell adherens junctions (AJs) in various tissues and cell lines. Afadin has one PDZ domain, three proline-rich regions, and one actin filament-binding domain. We found here that afadin directly interacted with a family of the immunoglobulin superfamily, which was isolated originally as the poliovirus receptor-related protein (PRR) family consisting of PRR1 and -2, and has been identified recen ...[more]